RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-497a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; etc.
Target
Reck
Pathway
NA
PubMed ID
Title
The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis
Year
2017
Function
"MiR-497-5p was significantly upregulated both during myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSCs) and in the lung tissues of a pulmonary fibrosis model. Reversion-inducing cysteine-rich protein with kazal motifs (Reck) was one of the target genes of miR-497-5p, and Reck could suppress the expression of matrix metalloproteinase-2 (Mmp2) and Mmp9, which could activate latent transforming growth factor-B1 (TGF-B1). Upregulation of miR-497-5p could induce LR-MSCs to differentiate into myofibroblasts and promote pulmonary fibrogenesis, while inhibition of its expression could effectively retard these processes."